Lake Victoria Basin covers an area of 250,000 km² with the lake taking 68,000 km². The basin has a population of 35 - 40 million people, with rapidly growing secondary towns, which has resulted in unplanned, sponteneous and unsustainable growth, run-down and non-existent basic infrastructure and services and significant negative impacts on the environment and fragile ecosystem of the lake.

Musambwa Islands are some of the smallest islands located in Lake Victoria in the Rakai District. Despite their size, they support large populations of African breeding birds like the Grey Headed Gull, Greater Cormorant, Little Egret and the Long-tailed Cormorant. Due to their importance to birds of global significance, the islands have been recognized as an Important Bird Area. The islands are known to be the largest breeding site in Africa for Grey Headed Gulls.

Kajulu and Nyando (both upstream) and Dunga (downstream) wetlands are located in Kisumu County. Upstream land is largely privately owned and mainly used for agriculture, energy needs and water. Deforestation and water diversion upstream worsen soil loss, leading to siltation and agro-chemical deposits downstream, which then leads to eutrophication of wetland ecosystems, reduced rainfall and reduced water flow to downstream swamps. All of this combines to cause a loss of wetland biodiversity, low crop output hence worsening food insecurity situation.

Yala wetland is a biodiversity rich and diverse ecosystem comprised of the Yala River, Yala swamp and numerous satellite lakes which serve as habitat for birds, haplochromines and cichlid fish species that long disappeared in Lake Victoria and numerous other species. The wetland faces anthropogenic threats such as reclamation of wetlands for farming, burning and over-harvesting for papyrus crafts and cooking fuel, fishing grounds, accessibility paths and sand harvesting.

BirdLife Partners from Kenya (NatureKenya), Uganda (NatureUganda), Rwanda (Association pour la Conservation de la Nature au Rwanda) and Burundi (Association Burundaise pour la Protection des Oiseaux) are implementing a project in the Lake Victoria Basin which aims to empower local organizations so that they are better equipped to address the linked challenges of poverty and biodiversity loss. Lake Victoria is Africa's largest lake, and the largest tropical lake in the world. The swamps, forests and islands in and around Lake Victoria are important for a diversity of wildlife.

Dansk Ornitologisk Forening (DOF) and BirdLife partners in the South (Nature Kenya, Nature Uganda and Bird Conservation Nepal (BCN)), are running a three-year project that began in 2015. The project places a strong emphasis on promoting equality of women and their access to programme benefits and participation, addressing inclusion of indigenous and other marginalised groups, networking and strengthened influence of local civil society groups_and advocacy within the national contexts of programme partner countries.

The Mara River basin covers a surface of 13,325 km², of which approximately 65 percent is located in Kenya and 35 percent in Tanzania. From its sources in the Mau Escarpment, the river flows for about 400 km and drains into Lake Victoria. The basin is among the most important river basins in East Africa as it traverses the world-famous Maasai Mara Serengeti ecosystem recently declared one of the new seven natural wonders of the world.

The Nakasongola District Climate Change Pilot Project documented and shared indigenous knowledge on climate change and contributed to the ongoing debates on how best to mitigate and adapt to climate change in the Nakasongola district in Uganda, while also informing practitioners' understanding of climate change causes, manifestations and effects at local levels. By creating awareness among local landowners and farmers on the value of indigenous tree species adapted to the harsh environment, the project decreased land clearing and persuaded farmers to preserve trees.